Raman spectroscopy - advanced optical analysis technology
Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.
Specs at a glance
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Laser wavelength
785 nm, 1000 nm -
Wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: PG13.5 for industry standard sensor housings, welded port connectors available
Surface finish: Ra 15 with electropolish
Adhesive: USP Class VI and ISO993 compatible -
Sterilization method
CIP/SIP
Field of application
The Raman Rxn-45 probe capitalizes on the power of Raman in bioprocess manufacturing by measuring multiple, specific components in real-time for continuous, around-the-clock process feedback. It also meets the daunting sampling requirements of compliance, sterilization, port compatibility, and convenience. The Raman Rxn-45 probe was designed for installation in development and cGMP stainless-steel reactors and is successfully used to provide an analytical “eye” into large-scale bioprocesses.
Cell culture: glucose, lactate, amino acids, cell density, titer, and more
Fermentation: glucose, glycerol, acetate, methanol, ethanol, biomass, and more
Benefits
Measures multiple components in real-time for automated 24/7 process feedback
Provides long-term measurement stability
Offers a suitable surface finish for cGMP manufacturing
Provides compatibility with industry standard bioreactor side ports and sensor housings
Offers the flexibility of being installed in development and production reactors
Reduces sterilization and cleaning burdens with CIP/SIP standard compatibility
Extended selection
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High-end products
- Highly functional and convenient
Technical excellence
Simplicity
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Standard products
- Reliable, robust and low-maintenance
Technical excellence
Simplicity
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Specialized products
- Designed for demanding applications
Technical excellence
Simplicity
Variable
| FLEX selections | Technical excellence | Simplicity |
|---|---|---|
Fundamental selection Meet your basic measurement needs |
Technical excellence
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Simplicity
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Lean selection Handle your core processes easily |
Technical excellence
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Simplicity
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Extended selection Optimize your processes with innovative technologies |
Technical excellence
|
Simplicity
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Xpert selection Master your most challenging applications |
Technical excellence
|
Simplicity
Variable |
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Technical Information (TI)
Rxn-45 Raman spectroscopic probe Technical Information
English version - 12/2024
System design and specifications for the Raman Rxn-45 probe
EN More 13/12/202403/08/202214/09/2021Language:
English
Version:
13/12/2024
File size:
352.9 KB
File name:
TI01633CEN_0323.pdf
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34 documents
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Technical Information (TI)
Rxn-45 Raman spectroscopic probe Technical Information
System design and specifications for the Raman Rxn-45 probe
EN Select other language 13/12/202403/08/202214/09/2021Language:
English
Version:
13/12/2024
File size:
352.9 KB
File name:
TI01633CEN_0323.pdf
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Operating Instruction (BA)
Rxn-45 Raman spectroscopic probe Operating Instructions
Commissioning, operation, and maintenance details
for the Raman Rxn-45 probeEN Select other language 02/12/202403/08/202214/09/2021Language:
English
Version:
02/12/2024
File size:
806.9 KB
File name:
BA02169CEN_0323.pdf
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Short Instruction (KA)
Rxn-45 Raman spectroscopic probe Brief Operating Instructions
Quick start guide for the Raman Rxn-45 probe
EN Select other language 02/12/202403/08/202214/09/2021Language:
English
Version:
02/12/2024
File size:
565.8 KB
File name:
KA01549CEN_0323.pdf
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PU (Publication)
Advanced process and product control in fermentations - Raman spectroscopy for composition analysis in a lab or process
An overview of Raman spectroscopy analyzer systems (including the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, and Rxn-45
probe), powered by Kaiser Raman technology, for fermentation
compositional analysis in a lab or process applicable to biotechnology
in the food & beverage industry.Language:
English
Version:
03/03/2022
File size:
603 KB
File name:
PU01457CEN_0122.pdf
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PU (Publication)
Raman application guide for the life science industry - Trusted composition analysis for the life sciences
A guide to our Raman spectroscopy application notes for the
Life Science industry (featuring the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-20 probe, Rxn-45 probe,
Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single
use optic system / SUB, immersion optic, non-contact optic).Language:
English
Version:
19/04/2022
File size:
1.1 MB
File name:
PU01447CEN_0222.pdf
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PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner
Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).Language:
English
Version:
27/06/2024
File size:
1.9 MB
File name:
PU01585CEN_0124.pdf
-
-
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PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle
This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).Language:
Czech
Version:
06/09/2024
File size:
381.4 KB
File name:
PU01584CEN_0124_cz_view.pdf
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-
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PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー
Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム）や水質分
析センサ技術（Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E）などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。Language:
Japanese
Version:
04/10/2024
File size:
2.7 MB
File name:
PU01585CJA_0124_Graphic_EH biopharma trust.pdf
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PU (Publication)
ライフサイエンス産業向けのラマンアプリケーションガイド -ライフサイエンスのための信頼できる組成分析
ライフサイエンス産業向けラマン分光法アプリケーションノート（
ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プロー
ブ、Rxn-20プローブ、Rxn-45プローブ、Rxn-46プローブ、プローブ
オプティックアクセサリ（bIOオプティック、シングルユース向け
ラマンオプティックシステム/SUB、浸漬オプティック、非接触オプ
ティック）。Language:
Japanese
Version:
02/08/2024
File size:
1.4 MB
File name:
PU01447CJA_0222_Raman_App_Guide_for_LifeScience.pdf
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PU (Publication)
発酵における高度なプロセスと 製品の制御 -ラボまたはプロセスにおける 組成分析用のラマン分光法
食品・飲料産業のバイオテクノロジーに適用されるラボやプロセス
での発酵組成分析のための、Kaiserラマンテクノロジーを搭載した
ラマン分光アナライザーシステム（ラマンRxn2アナライザー、ラマ
ンRxn4アナライザー、Rxn-10プローブ、Rxn-45プローブを含む）の
概要。Language:
Japanese
Version:
02/08/2024
File size:
1.4 MB
File name:
PU01457CJA_0122_Adv_Process_Product_Control_Fermentations.pdf
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PU (Publication)
効率的なバイオ医薬品の製品開発ライフサイクルのために拡張性を優先
この技術文書では、ライフサイエンス産業におけるバイオプロセス
の競争優位性としての拡張性の重要性と、Endress+Hauserの拡張性
のあるラマンシステム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45
、Rxn-46、バイオマルチオプティックおよびスリーブ、フローフィ
ル、フローベンチ、シングルユース用Ramanオプティックシステム）
、水質分析センサ技術、および水質分析製品ラインナップ
（LiquilineCM44P、CM442、OUSAF44、OUSBT66、Memosens CPS61E、
CLS82E、COS81E、CLS82E）について考察しています。Language:
Japanese
Version:
04/10/2024
File size:
1.3 MB
File name:
PU01584CJA_0124_Scalability in biopharma development.pdf
-
-
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PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle
This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).Language:
English
Version:
27/06/2024
File size:
753.7 KB
File name:
PU01584CEN_0124.pdf
-
-
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PU (Publication)
Lab-to-process monitoring & control in Life Sciences - Reliable measurement of bioprocess physical and chemical properties
A combined product list of analysis offerings from both Optical Analysis
and LIquid Analysis for bioprocessing applications in the life science
industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer,
Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly,
Rxn-45 probe, Rxn-46 probe, Raman optic system for single use,
Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E,
Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E,
Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and
Memobase software).Language:
English
Version:
11/04/2024
File size:
776.1 KB
File name:
PU01484CEN_0224.pdf
-
-
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PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner
Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).Language:
Czech
Version:
06/09/2024
File size:
353 KB
File name:
PU01585CEN_0124_cz_view.pdf
-
-
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Competence Brochure (CP)
Faster market entry, higher yields, and improved quality - Real-time, inline bioprocess monitoring and control from lab to GMP with Raman Rxn systems & Memosens digital sensors
This eBook highlights the Endress+Hauser inline analysis portfolio
for bioprocessing including Raman spectroscopy systems
(Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic
and sleeve, flow cell and flow bench, Raman optic system for single use)
and liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E)
in the Life Science industry.Language:
English
Version:
21/06/2024
File size:
1.9 MB
File name:
CP01579CEN_0124.pdf
-
-
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Competence Brochure (CP)
Faster market entry, higher yields, and improved quality - Real-time, inline bioprocess monitoring and control from lab to GMP with Raman Rxn systems & Memosens digital sensors
This eBook highlights the Endress+Hauser inline analysis portfolio
for bioprocessing including Raman spectroscopy systems
(Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic
and sleeve, flow cell and flow bench, Raman optic system for single use)
and liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E)
in the Life Science industry.Language:
Czech
Version:
06/09/2024
File size:
1.7 MB
File name:
CP01579CEN_0124_cz_view.pdf
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-
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Competence Brochure (CP)
市場投入の加速、歩留まりの増加、品質の向上 Raman RxnシステムとMemosensデジタルセンサによる、ラボからGMP までのリアルタイムでのインラインバイオプロセス監視と制御
この eBook では、ライフサイエンス業界におけるラマン分光シス
テム (Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、バイオ
マルチオプティックおよびスリーブ、フローセルおよびフローベン
チ、シングルユース向けラマンオプティックシステム) や水質分析
センサ技術 (Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E) を含む、バイオプロ
セス向けの Endress+Hauser インライン分析製品ラインナップを紹
介しています。Language:
Japanese
Version:
02/12/2024
File size:
5.7 MB
File name:
CP01579CJA_0124_Fast-entry-yields_Inline-monitoring_Raman-Memosens.pdf
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Competence Brochure (CP)
Raman spectroscopy food & beverage application guide - Trusted technology for composition analysis in a laboratory or process environment
A guide to Raman spectroscopy application notes for the
food & beverage industry (featuring studies using the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe,
Rxn-20 probe, Rxn-45 probe, and the immersion optic
and non-contact optic).Language:
English
Version:
17/02/2022
File size:
859 KB
File name:
CP01489CEN_0122.pdf
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Case Study (CS)
ラマンアップストリームバイオプロセス制御 - Nicro社がファーメンタ用のターンキーソリューションを提供
Nicro社が、Kaiser Raman テクノロジーを用いたラマン分光法（
Raman Rxn2アナライザおよびRaman Rxn-45プローブを含む）を、ラ
イフサイエンス産業の高度なバイオプロセス制御にどのように使用
したかを検証するケーススタディです。Language:
Japanese
Version:
04/10/2024
File size:
2.7 MB
File name:
CS01903CJA_0124_Raman upstream bioprocess control.pdf
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-
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Case Study (CS)
Raman upstream bioprocess control - Nicro provides turnkey solutions for fermenters
A case study that examines how Nicro used Raman spectroscopy
(including a Raman Rxn2 analyzer and a Raman Rxn-45 probe),
powered by Kaiser Raman technology, for advanced bioprocess
control in the life science industry.Language:
English
Version:
11/06/2024
File size:
2.4 MB
File name:
CS01903CEN_0124.pdf
-
-
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Case Study (CS)
Raman upstream bioprocess control - Nicro provides turnkey solutions for fermenters
A case study that examines how Nicro used Raman spectroscopy
(including a Raman Rxn2 analyzer and a Raman Rxn-45 probe),
powered by Kaiser Raman technology, for advanced bioprocess
control in the life science industry.Language:
Czech
Version:
06/09/2024
File size:
588.1 KB
File name:
CS01903CEN_0124_cz_view.pdf
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-
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Innovation (IN)
バイオプロセスにおけるラマン技術 - 拡張性のあるin situバイオプロセス監視と高度なプロセス制御
Kaiserラマンテクノロジーを搭載した、バイオプロセス/バイオ医
薬品業界向けのラマン分光アナライザーとプローブ製品ラインナッ
プ（ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プ
ローブ、Rxn-45プローブ、Rxn-46プローブ、プローブオプティック
アクセサリ（bIOオプティック、シングルユース向けラマンオプテ
ィックシステム、バイオマルチオプティックおよびバイオスリーブ
と組合せ、ラマンフローアセンブリを含む）の概要パンフレット。Language:
Japanese
Version:
02/08/2024
File size:
7.2 MB
File name:
IN01228CJA_0223_Raman technology in bioprocessing.pdf
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-
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Innovation (IN)
Raman technology in bioprocessing - Scalable in situ bioprocess monitoring enabling advanced process control
An overview brochure about our Raman spectroscopy analyzer
and probe portfolio, powered by Kaiser Raman technology, for
the bioprocessing / biopharmaceutical industry (including the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe,
Rxn-45 probe, Rxn-46 probe, and probe accessory optics (bIO-Optic,
Raman single use optic system, bio multi optic with bio sleeve, and
Raman flow assembly), powered by Kaiser Raman technology.Language:
English
Version:
19/06/2023
File size:
6.8 MB
File name:
IN01228CEN_0223.pdf
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-
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Innovation (IN)
ラマン分光プローブ - 堅牢な分光分析による化学組成分析
ラマン分光法プローブ製品ラインナップに関する概要パンフレット
です。この製品ラインナップには、Rxn-10プローブ、Rxn-20プロー
ブ、Rxn-30プローブ、Rxn-40プローブ、Rxn-41プローブ、Rxn-45プ
ローブ、Rxn-46プローブ、およびプローブオプティクアクセサリ
（bIOオプティック、シングルユース向けラマンオプティックシス
テム/SUB、浸漬オプティック、非接触オプティック）が含まれてい
ます。これらはすべて、Kaiserラマンテクノロジーによって動作し
ます。Language:
Japanese
Version:
24/06/2024
File size:
5.4 MB
File name:
IN01225CJA_0121_Raman_spectroscopic_probes.pdf
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Innovation (IN)
Raman spectrographic probes - Robust optical measurement of chemical composition
An overview brochure about our Raman spectroscopy probe
portfolio including the Rxn-10 probe, Rxn-20 probe, Rxn-30 probe,
Rxn-40 probe, Rxn-41 probe, Rxn-45 probe, Rxn-46 probe, and
probe accessory optics (bIO-Optic, Raman single use optic system /
SUB, immersion optic , non-contact optic), powered by Kaiser Raman
technology.Language:
English
Version:
26/10/2021
File size:
4.9 MB
File name:
IN01225CEN_0121.pdf
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Innovation (IN)
Mesure optique robuste de la composition chimique
-
Language:
French
Version:
16/03/2023
File size:
776 KB
File name:
IN01225CFR.pdf
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Innovation (IN)
Technologie Raman pour les bioprocédés
Surveillance évolutive des bioprocédés in situ et contrôle
avancé des processLanguage:
French
Version:
08/02/2024
File size:
1.3 MB
File name:
IN01228CFR-Raman bioprocedes.pdf
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White paper (WP)
How Raman ensures product quality from lab-to-process in biopharma
A whitepaper about using Raman spectroscopy for lab-to-process
chemical composition measurement in biopharmaceutical manufacturing
(applicable to the Endress+Hauser Raman analyzer and probe
bioprocessing portfolio, powered by Kaiser Raman technology
(including the Raman Rxn2 analyzer, Raman Rxn4 analyzer,
Rxn-10 probe, Rxn-45 probe, Rxn-46 probe, bIO-Optic, Raman
single use optic system, immersion optic , non-contact optic).Language:
English
Version:
17/02/2022
File size:
350.8 KB
File name:
WP01172CEN_0222.pdf
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-
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White paper (WP)
Revolutionizing biomanufacturing - Real-time, inline bioprocess measurement across the product lifecycle
This white paper examines the importance of
inline measurement techniques like Raman spectroscopy
systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45,
Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use) and liquid
analysis sensor technology (Liquiline CM44P, CM442 and
USAF44, OUSBT66 and Memosens CPS61E, CLS82E,
COS81E, CLS82E) to gain a bioprocessing competitive
advantage in the Life Science industry.Language:
Czech
Version:
06/09/2024
File size:
300.1 KB
File name:
WP01220CEN_0124_cz_view.pdf
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-
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White paper (WP)
バイオマニュファクチャリングの革新 - 製品ライフサイクル全体にわたるリアルタイムのインラインバイオプロセス測定
このホワイトペーパーでは、ライフサイエンス産業におけるバイオ
プロセスの競争優位性を獲得するために、ラマン分光システム
（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、バイオマル
チオプティックおよびスリーブ、フローフィル、フローベンチ、シ
ングルユース用Ramanオプティックシステム）や水質分析センサ技
術（Liquiline CM44P、CM442、USAF44、OUSBT66、Memosens CPS61E
、CLS82E、COS81E、CLS82E）といったインライン測定技術の重要性
について考察しています。Language:
Japanese
Version:
04/10/2024
File size:
2.3 MB
File name:
WP01220CJA_0124_Real-time inline bioprocess measurement.pdf
-